【Cell重磅】 全球最大的蜱虫基因组数据出炉！赵方庆/曹务春首次揭示蜱虫的遗传多样性，为控制蜱虫和蜱虫传播疾病奠定基础
文章第一作者为军事科学院军事医学研究院微生物流行病研究所贾娜副研究员、中国科学院北京生命科学研究院王金锋副研究员、军事科学院军事医学研究院微生物流行病研究所石文强助理研究员、中国科学院北京生命科学研究院杜立锋博士与军事科学院军事医学研究院微生物流行病研究所孙毅研究员。
Title：Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities
DOI：10.1016/j.cell.2020.07.023
Abstact：Among arthropod vectors, ticks transmit the most diverse human and animal pathogens, leading to an increasing number of new challenges worldwide. Here we sequenced and assembled high-quality genomes of six ixodid tick species and further resequenced 678 tick specimens to understand three key aspects of ticks: genetic diversity, population structure, and pathogen distribution. We explored the genetic basis common to ticks, including heme and hemoglobin digestion, iron metabolism, and reactive oxygen species, and unveiled for the first time that genetic structure and pathogen composition in different tick species are mainly shaped by ecological and geographic factors. We further identified species-specific determinants associated with different host ranges, life cycles, and distributions. The findings of this study are an invaluable resource for research and control of ticks and tick-borne diseases.
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